Table of Contents
Natural Products are generally defined as chemicals produced by living organisms. There are more precise definitions of NPs, but they do not consistently achieve consensus. Some NPs group together all the small molecules that result from metabolic reactions; others only classify as “NP” products of secondary or non-essential metabolism.
This review excluded molecules involved in primary or essential metabolism, such as energy or anabolic pathways. And also to consider only molecules produced by living organisms for “higher” functions such as signaling or defense to be achieved.
And even less than 1500 Da. As with most definitions in the life sciences, however, the boundary between primary and secondary metabolites is very narrow and depends on the potential application of the molecule for categorization. This categorization justifies the need for NP databases of molecules.
About The Journal
Chemical and biological research is concerned with naturally occurring chemical compounds that generally have pharmacological or physical activity in drug discovery and development.
Natural Products Chemistry & Research focuses on articles about studying the chemistry and biochemistry of natural products or the biology of living systems from which they are derived.
Therefore, the journal encompasses many areas within its discipline to provide a platform for authors to contribute. The editorial team promises to peer-reviewed manuscripts submitted for publication quality.
Classification of Natural Products
1) Based on the molecular structure of the backbone – open-chain aliphatic, alicyclic and cyclo paraffinic, aromatic, benzoic, and heterocyclic
2) Based on physiological activity – plant or animal origin
3) Based on chemotaxonomy: check the components of the plant
4) Based on biogenesis: biosynthetic pathways of plant and animal metabolic products.
The main classes of natural products are described below:
- Photosynthesis or gluconeogenesis I monosaccharides I polysaccharides (cellulose, chitin, glycogen, etc.)
- Acetate I fatty acids and polyketide route
- Shikimate I-way, aromatic amino acids, and phenylpropanoids
- Terpenoids and steroids of the mevalonate pathway and the methyletritrite-phosphate pathway I
- Amino acids I alkaloids
Therefore, the chemistry of natural products is an independent field of chemical research that plays an essential role in chemistry in preclinical and clinical studies for drug research.
It is associated with the isolation and purification of chemicals. So It developed by using various methods of determining chemical structure by NMR studies and identifying pharmacological domains of the chemical.
Synthetic strategies and tactics are used in organic chemistry by providing sophisticated targets to bring the product’s biological activity to the target site.
Natural products motivate and help develop new variants using old and new chemical reactions. For example, Evans aldol reaction, less acute epoxidation, Woodward cis hydroxylation, etc.
Research has been conducted to study the biochemical pathways involved in understanding the synthesis of natural products.